Join bluebird bio’s Cambridge-based genome editing team to help bring innovative immunotherapy products into the clinic. In this role, you will contribute to the preclinical and clinical development gene-edited CAR/TCR T cells for oncology indications. This position will utilize your strong scientific background, track record of exceptional experimental technique, and the ability to design and implement creative solutions to complex cell therapy and gene editing questions.
About the role:
- Develop and optimize protocols for T cell gene editing, including; megaTAL delivery methods, culture conditions, scale up, and multiplexing
- Evaluate gene editing approaches to improve the efficacy of CAR and TCR based T cell therapeutics in vitro and in vivo
- Design and develop immunological assays to characterize genetically engineered and edited primary T cells
- Lead a team of 1-2 associate scientists
- Work together with project leaders, immunotherapy department, and other groups across bluebird bio to drive project success
- Exercise independent judgment in development of new methods, techniques and evaluation criteria
- PhD in Immunology, Cell Biology, Molecular Biology, Bioengineering, Biochemistry, or a related discipline. Post-doctoral experience welcome but not required. Some industry experience preferred but not required.
- Solid understanding of immunology, including familiarity with T cell development and function, immune receptor signaling and the biology of chimeric antigen receptors
- Applied experience in gene-edited T cell therapies
- Expertise with in vitro models of cancer and cellular immunotherapy, including immunological assays to assess T cell function
- Experience working in animal models of adoptive immunotherapy a plus
- Familiarity with gene editing technique and applications, including CRISPR, TALEN, ZFNs or Homing Endonuclease/megaTAL, is a plus
- Strong technical background with standard laboratory methods, including: polychromatic flow cytometry; molecular biology and cloning; virus handling and production; PCR; ELISA; intracellular staining; western blotting; in-vitro transcription
- Ability to work effectively in a collaborative team environment where results are achieved through influence, cooperation, and the incorporation of multiple points of view
- Independently motivated, detail oriented and good problem solving ability
- Excellent organizational skills, with an ability to embrace change and multi-task in an extremely fast-paced environment
- Excellent communications skills and ability to influence across multiple functions.
- Be ready to embrace the principles of the bluebird bio culture: b colorful, b cooperative, and b yourself
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