Sr Associate Scientist II / Scientist I, Process Development

Cambridge, MA

Stem cell therapies


bluebird bio is developing potentially transformative, one-time gene therapies for severe genetic and orphan diseases. At the heart of bluebird bio’s product creation efforts is its broadly applicable gene therapy platform for the development of new treatments for diseases with few or no clinical options. bluebird bio has two clinical stage product candidates in development, one for childhood cerebral adrenoleukodystrophy (CCALD) and one for beta-thalassemia major/sickle cell disease, and an early stage oncology program in partnership with Celgene Corporation.

Join bluebird bio’s enthusiastic and collaborative team by contributing to the overall success of our novel gene therapy approach.  The focus of this position is to provide support for the development of the stem cell transduction and manufacturing processes. We are looking for an innovative scientist with the breadth of experience and drive to implement our vision for this function.

Activities include:

  • Support studies into variables that effect recovery of CD34+ cells from mobilized peripheral blood and bone marrow from normal and disease subjects
  • Perform complex technical work related to stem cell biology, CD34+ enrichment, molecular biology, tissue culture, and RT-PCR
  • All aspects of mammalian cell culture, including media and buffer preparation, culture initiation, propagation, and cryopreservation of cells, including primary human cells from commercial and/or patient sources 
  • Use flow cytometry and other immunological assays to characterize human primary cells isolated from peripheral blood and bone marrow
  • Perform both manual and automated cell separation techniques
  • Coordinate acquisition of samples from clinical sites, including communications with internal Quality, Clinical and Logistics functions
  • Organize, analyze and interpret data
  • Communicate results verbally and in writing, generate technical reports
  • Adhere to project timelines
  • Performance of general laboratory tasks, including maintenance of equipment
  • Maintain accurate and reliable record keeping including database management, batch records, notebooks, and all other pertinent documentation
  • Occasional evening and weekend work required

Preferred Qualifications:

  • For the Scientist 1 level: MS cell biology, immunology or related discipline with at least 6 years' experience in process development in the biotech or pharma industry or PhD and 2 years’ industry experience
  • For the Senior Associate Scientist II Level: B.S. in a scientific discipline and at least 8+ years of related laboratory experience or M.S. with at least 6+ years of related laboratory experience.
  • Experience working with blood products
  • Process development experience for cell/gene therapies is required, biologics is a plus
  • Experience with developing or manufacturing autologous cell therapies is required
  • Experience with automated and manual cell separation techniques including the Miltenyi CliniMACS and density based gradient separations is desirable
  • Experience with GMP and quality systems helpful
  • Well versed in a variety of cell based methods with a strong understanding of tissue culture, cell biology, immunoassays, and general laboratory techniques.
  • Willingness to work with lentiviral vector and human biological samples (viral vector biology experience a plus)
  • Working knowledge of various computer software, hardware, and standard office sufficient to record scientific data and results, and prepare reports.
  • Ability to work in a team environment, meet deadlines, and prioritize work
  • Ability to work effectively in a collaborative team environment where results are achieved through influence and the incorporation of multiple points of view
  • Independently motivated, detail oriented and good problem solving ability
  • Excellent organizational skills, sufficient to multi-task in a fast-paced environment with changing priorities
  • Strong verbal and written skills; ability to provide focus and clarity; able to handle confidential information and material appropriately
  • Be ready to embrace the principles of the bluebird bio culture: b colorful, b cooperative, and b yourself



This is an exciting time to join the field of gene therapy in general, and to become a part of the bluebird bio team in particular. bluebird bio is a publicly traded company on the NASDAQ Global Select Market and trades under the symbol BLUE.  We were recently named to the 2012 FierceBiotech Fierce 15. We offer a fast-paced, dynamic, collaborative, colorful, and scientifically rigorous environment, with all the fun and passion that a start-up provides, plus an excellent benefits package that includes stock options, commuter/parking benefit, etc.

To be considered for this exciting career opportunity, please apply through our website.

bluebird bio, 150 Second St, Cambridge, MA 02141

bluebird bio will only accept job applications from candidates who are properly documented with authorization to work in the United States.

Note to Employment Agencies: Please do not forward any agency resumes. bluebird bio is not responsible for any fees related to resumes that are unsolicited.


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bluebird bio will only accept job applications from candidates who are properly documented with authorization to work in the United States.

Note to Employment Agencies: Please do not forward any agency resumes. bluebird bio is not responsible for any fees related to resumes that are unsolicited.