Senior Associate Scientist, Process Development

Cambridge, MA

Novel Gene Therapy Platforms

bluebird bio is developing potentially transformative, one-time gene therapies for severe genetic and orphan diseases. At the heart of bluebird bio’s product creation efforts is its broadly applicable gene therapy platform for the development of new treatments for diseases with few or no clinical options. Our clinical programs include Lenti-D™, currently in a Phase 2/3 study, called the Starbeam Study, for the treatment of cerebral adrenoleukodystrophy, and LentiGlobin®, currently in three clinical studies: a global Phase 1/2 study, called the Northstar Study, for the treatment of transfusion-dependent ß-thalassemia (also known as ß-thalassemia major); a single-center Phase 1/2 study in France (HGB-205) for the treatment of transfusion-dependent ß-thalassemia or severe sickle cell disease; and a separate U.S. Phase 1 study for the treatment of severe sickle cell disease (HGB-206). Our Phase 1 immuno-oncology application using CAR T cell technology directed towards B cell maturation antigen (BCMA) in multiple myeloma (CRB-401), recently demonstrated preliminary results with 100% of 15 evaluable patients achieving an objective response and 89% achieving an overall response in relapsed refractory patients. We also have ongoing preclinical immuno-oncology programs targeting hematological and solid tumors, as well as discovery research programs utilizing megaTAL/homing endonuclease gene editing technologies.

Join bluebird bio’s enthusiastic and collaborative team by contributing to the overall success of our novel gene therapy approach.  The focus of this position is to provide support for the development of manufacturing processes for T cell based therapies in oncology. We are looking for a motivated associate scientist/senior associate scientist with the experience and drive to take ownership over important process development projects.

Activities include:

  • Assist in the design and testing of new equipment and technologies for closed system manufacturing of autologous cellular therapies
  • Assist in developing, improving, and executing procedures for the isolation, transduction, gene editing, expansion and cryopreservation of autologous cells for the treatment of a variety rare genetic diseases, hematological malignancies and other cancers
  • Assist in designing and evaluating new assays for the characterization of drug product
  • Perform complex technical work related to cell biology, gene transfer, and molecular biology, including tissue culture, flow cytometry and RT-PCR
  • Responsible for maintaining inventories and archiving experimental samples
  • Assist in the review and editing of standardized procedures
  • Must be willing to have a flexible schedule based on experimental and company needs
  • Performance of general laboratory tasks, including maintenance of equipment
  • Maintain accurate and reliable record keeping including database management, batch records, notebooks, and all other pertinent documentation
  • Assist in technology transfer and training of subject matter experts

Preferred Qualifications:

  • BS or MS in cell biology, immunology or related discipline with at least 4 years' experience in the biotechnology or pharmaceutical industry. Experience with cGMP manufacturing of Phase I/II cellular and gene therapies is a plus
  • Multicolor FACS staining and operating various types of flow cytometers.
  • Experience with electroporation
  • Have superb aseptic technique, and experience with isolating, and culturing primary cells
  • Willingness to work with lentiviral vector and human biological samples including leukapheresis and whole blood
  • Ability to take ownership of projects and results
  • Independently motivated, detail oriented and good problem solving ability
  • Excellent organizational skills, sufficient to multi-task in a fast-paced environment with changing priorities
  • Strong verbal and written skills; ability to provide focus and clarity; able to handle confidential information and material appropriately
  • Working knowledge of various computer software, hardware, and standard office, sufficient to record scientific data and results, and prepare reports.
  • Ability to work in a team environment, meet deadlines, and prioritize and balance work from multiple individuals
  • Be ready to embrace the principles of the bluebird bio culture: b colorful, b cooperative, and b yourself


This is an exciting time to join the field of gene therapy in general, and to become a part of the bluebird bio team in particular. bluebird bio is a publicly traded company on the NASDAQ Global Select Market and trades under the symbol BLUE.  We were recently named one of MIT Technology Review’s 50 Smartest Companies of 2017. The Boston Business Journal recently rated us in the top ten of 2017’s best places to work. We offer a fast-paced, dynamic, collaborative, colorful, and scientifically rigorous environment, with all the fun and passion that a start-up provides, plus an excellent benefits package that includes stock options, commuter/parking benefit, etc.

To be considered for this exciting career opportunity, please apply through our website.

bluebird bio, 150 Second St, Cambridge, MA 02141

bluebird bio will only accept job applications from candidates who are properly documented with authorization to work in the United States.

Note to Employment Agencies: Please do not forward any agency resumes. bluebird bio is not responsible for any fees related to resumes that are unsolicited.

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bluebird bio will only accept job applications from candidates who are properly documented with authorization to work in the United States.

Note to Employment Agencies: Please do not forward any agency resumes. bluebird bio is not responsible for any fees related to resumes that are unsolicited.